da Silva Fernandes, JaimeSchuelter-Trevisol, FabianaLobor Cancelier, Ana CarolinaGomes de Sousa, DaianaL. Atkinson, RichardTrevisol, Daisson José2021-05-252021-05-252021-031476-5497https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983349/pdf/41366_2021_Article_805.pdfhttps://repositorio.animaeducacao.com.br/handle/ANIMA/13034ntroduction Obesity has numerous etiologies and includes biological factors. Studies have demonstrated that the human adenovirus subtype 36 (Adv36) is an adipogenic agent and causes metabolic alterations. Study results on the prevalence of Adv36 and clinical effects in humans vary substantially. This was a systematic review to summarize the studies on the prevalence of Adv36 infection and its association with human obesity. Methods A systematic literature review was conducted using the preferred reporting items for systematic reviews and meta analysis (PRISMA). Observational or experimental studies found in the Medline, Embase, LILACS, Science Direct and SciELO databases that presented results on the prevalence of Adv36 in humans were included. Results Thirty-seven studies were screened. A total of 10,300 adults aged 18–70 years and 4585 children and adolescents aged 3–18 years were assessed. The average prevalence of Adv36 among adults was 22.9%, ranging from 5.5% to 49.8%. Among children and adolescents, the average prevalence of Adv36 was 28.9%, ranging from 7.5% to 73.9%. There was a positive statistical relationship between Adv36 and weight gain, obesity, or metabolic changes in 31 studies. However, in four studies there was no association with obesity, and in one, no association was described. One of the studies showed an inverse correlation, i.e., Adv36 was a protective factor against obesity. Conclusion Strong evidence suggested a positive association between viral infection and obesity. However, due to the multi causality of obesity and heterogeneity of studies, diagnostic tests should be standardized and easily accessible by the population to estimate the overall prevalence of Adv36 infection and its association with obesity.000-000Meio digitalenAtribuição-NãoComercial-SemDerivados 3.0 Brasiladenovírus 36 humanoobesidadesobrepeosArtigo completo publicado em periódico