Fortunato, Jucélia JeremiasGomes, Thainá Cidreira dos SantosAbrahão, Sabini2022-12-062022-12-062022https://repositorio.animaeducacao.com.br/handle/ANIMA/27293Sepsis is a life-threatening complex organ dysfunction resulting from dysregulated host responses to infection. This study aimed to evaluate whether maternal immune activation in the gestational period can activate neuroinflammation factors in offspring in adulthood after polymicrobial sepsis, and result in protection against behavioral changes. The study was performed on the offspring of sows exposed to LPS or saline in the prenatal period. Upon completing 60 days, sepsis was induced by CLP or sham. The animals were then divided into 8 groups: SAL+SHAM female and male, SAL+CLP female and male, LPS+SHAM female and male, LPS+CLP female and male. The behavior of the groups in the open field were analyzed in the parameters grooming, defecation, rearing and in forced swimming the parameters swimming, immobility, diving. The LPS+CLP groups, In view of the results obtained, it can be said that maternal immune activation associated with systemic inflammation induced by sepsis produced ambivalent results, resulting in anxious, depressive or stressed behaviors in some groups and improved memory in others, evidencing the beneficial effect of conditioning.57 f.ptAtribuição-NãoComercial-SemDerivados 3.0 BrasilSepseAtivação imunematernaComportamentoArtigo Científico