Fisioterapia
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Navegando Fisioterapia por Assunto "Analgesia"
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Artigo Científico Acesso embargado Fotobiomodulação com diodo emissor de luz 630nm acelera cicatrização e promove analgesia leve em camundongos fêmeas no modelo de dor pós-operatória(2019) Oliveira, Nathalia Junckes dePurpose: the present study evaluated the efficacy of light-emitting diode (LED) photobiomodulation in tissue repair and analgesia in order to understand part of the mechanism of action of led during the inflammatory phase of surgical incision in an animal model. Methods: a plantar surgical incision model was used in adult female swiss mice divided into four experimental groups (n = 8): sham led off; sham led on; led off incision and led on incision. The 630 nm led photobiomodulation with 2 J/cm2 irradiation was applied daily at the surgical incision site until the fifth postoperative day for 22 s. Mechanical hypersensitivity by von frey test (0.6 g), as well as incision healing rate by morphometry were evaluated daily. At the end of led treatment, on the fifth day after the incision, paw skin samples were dissected and levels of interleukin-4 (IL-4) were quantified by enzyme linked immunosorbent assay (ELISA) and the content of hydroxyproline by colorimetric reaction to evaluate collagen levels at the healing site. Results: the plantar incision surgical procedure induced mechanical hyperalgesia and the led treatment was able to reduce this effect only on the 3rd day after the incision, remaining for 0.5 h after treatment. The healing process was accelerated by led treatment and was evident on the 4th day after surgery. On the other hand, although il-4 levels increased after incision, led treatment did not change these concentrations. Hydroxyproline levels were not significantly different between groups. Conclusion: led photobiomodulation accelerated tissue repair and promoted analgesia in an animal model of surgical incision.