Ação da hialuronidase no manejo de intercorrências por ácido hialurônico: uma revisão narrativa
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
HERRLEIN, Adriane Lukow
BRUCK, Vanise Conceição Bezerra Pandolfo
Orientador
BARROCO, Caroline de Araújo
Coorientador
Larissa Araújo
Resumo
O envelhecimento é um processo multifatorial, decorrente de fatores intrínsecos, os quais não podem ser evitados, pois é causado pela passagem natural do tempo, afetam as estruturas moles, esqueléticas e muscular. E fatores extrínsecos, provocados pelo ambiente e pelos hábitos de vida, os quais interagem com a pele como o fotoenvelhecimento e o tabagismo. Para tratar essas condições, procedimentos não cirúrgicos começaram a ser cada vez mais procurados por pessoas mais jovens para previnir e até retardar o envelhecimento. Uma substância que se mostrou eficaz é o ácido hialurônico (AH), que é biocompatível com nosso organismo e considerado seguro, com baixas taxas de complicações. Porém, assim como em qualquer procedimento, existem riscos, mesmo que mínimos, seja por imperícia do profissional ou por uma reação adversa do próprio organismo do paciente. Ocorrendo tais situações, é possível reverter fazendo uso da hialuronidase, uma enzima que dilui o ácido hialurônico, recomendada por ser eficaz e de fácil absorção. O presente estudo demonstra, através de uma revisão narrativa da literatura, a aplicação da hialuronidade em intercorrências de efeitos indesejáveis causadas pelo uso do ácido hialurônico. Foi realizada busca de artigos a partir dos descritores “ácido hialurônico, hialuronidase, efeitos adversos, tratamento, intercorrência, necrose, resultados da administração de hialuronidase para correção de complicações durante e após aplicação de ácido hialurônico”, consultados via PubMed, Google Acadêmico, na biblioteca virtual SciELO e DeCS/MeSH. A utilizaçãpo da enzima hialuronidase, mesmo ainda estando classificada como “off-label” para fins estéticos, mostrou-se uma opção muito eficaz no que diz respeito tanto a efeitos adversos de complicações agudas, como para reverter resultados indesejados e diluir biolimes, sendo essa uma técnica segura, eficaz e indispensável para os profissionais que atuam com AH.
Aging is a multifactorial process, as it results from the interaction and sum of several factors. These are intrinsic factors, which cannot be avoided, result from the natural passage of time, and affect soft, skeletal and muscular structures. And extrinsic factors, caused by the environment and lifestyle habits, which interact with the skin, such as photoaging and smoking. To treat these conditions, non-surgical procedures began to be increasingly sought after by younger people to prevent and even delay aging. A substance that has proven effective is hyaluronic acid (HA), which is biocompatible with our body and considered safe, with low complication rates. However, as with any procedure, there are risks, even if minimal, whether due to the professional's ineptitude or an adverse reaction from the patient's own body. If such situations occur, it is possible to reverse it by using hyaluronidase, an enzyme that dilutes hyaluronic acid, recommended because it is effective and easily absorbed. The present study demonstrates, through a narrative review of the literature, the application of hyaluronity in complications of undesirable effects caused using hyaluronic acid. A search for articles was carried out using the descriptors “hyaluronic acid, hyaluronidase, adverse effects, treatment, complications, necrosis, results of administration of hyaluronidase to correct complications during and after application of hyaluronic acid”, consulted via PubMed, Google Scholar, on SciELO and DeCS/MeSH virtual library. The use of the hyaluronidase enzyme, even though it is still classified as “offlabel” for aesthetic purposes, has proven to be a very effective option regarding both the adverse effects of acute complications, as well as reversing unwanted results and diluting biolimes, this being a safe, effective, and essential technique for professionals who work with HA.
Aging is a multifactorial process, as it results from the interaction and sum of several factors. These are intrinsic factors, which cannot be avoided, result from the natural passage of time, and affect soft, skeletal and muscular structures. And extrinsic factors, caused by the environment and lifestyle habits, which interact with the skin, such as photoaging and smoking. To treat these conditions, non-surgical procedures began to be increasingly sought after by younger people to prevent and even delay aging. A substance that has proven effective is hyaluronic acid (HA), which is biocompatible with our body and considered safe, with low complication rates. However, as with any procedure, there are risks, even if minimal, whether due to the professional's ineptitude or an adverse reaction from the patient's own body. If such situations occur, it is possible to reverse it by using hyaluronidase, an enzyme that dilutes hyaluronic acid, recommended because it is effective and easily absorbed. The present study demonstrates, through a narrative review of the literature, the application of hyaluronity in complications of undesirable effects caused using hyaluronic acid. A search for articles was carried out using the descriptors “hyaluronic acid, hyaluronidase, adverse effects, treatment, complications, necrosis, results of administration of hyaluronidase to correct complications during and after application of hyaluronic acid”, consulted via PubMed, Google Scholar, on SciELO and DeCS/MeSH virtual library. The use of the hyaluronidase enzyme, even though it is still classified as “offlabel” for aesthetic purposes, has proven to be a very effective option regarding both the adverse effects of acute complications, as well as reversing unwanted results and diluting biolimes, this being a safe, effective, and essential technique for professionals who work with HA.
Palavras-chave
Ácido hialurônico, Hialuronidase, efeito adverso