Cannabis sativa como alternativa para o tratamento de dor neuropática
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
CRUZ, Ana Julia Xavier Valle
ALVARENGA, Carolina Couto
FERREIRA, Lígia do Paço
NOGUEIRA, Marina Pedrosa
SOUZA, Naiara Vitória Lima de
Orientador
ASSIS, Danielle Nogueira de
Coorientador
PENAFORTE, Claudia Lopes
Resumo
A Cannabis sativa é usada por povos e culturas em distintas funções por milhares de anos. Canabinóides e fitocanabinoides têm se mostrado promissores de forma terapêutica. Dessa forma, o sistema endocanabinóide qualifica-se cada vez mais na modulação da dor, desempenhando um importante papel nos novos tratamentos via fitocanabinóides por funcionar como receptor de canabidiol. Este artigo de revisão visa compreender e disseminar mais informações sobre a planta como potencial tratamento para dor neuropática. Foram incluídos 46 estudos entre 2.619 artigos identificados. Foram utilizados artigos publicados na última década, na íntegra, com acesso livre e escritos na língua portuguesa e inglesa. Houve exclusão de artigos duplicados e resumos que não corroboravam com o objetivo do estudo. Através da pesquisa constatou-se que, apesar das limitações na metodologia e a falta de pesquisas longitudinais, a maioria dos estudos indicou redução da dor relatada e dos sintomas colaterais.
Cannabis sativa has been used by peoples and cultures in various functions for thousands of years. Cannabinoids and phytocannabinoids have shown promise therapeutically. Thus, the endocannabinoid system is increasingly recognized for its role in pain modulation, playing a crucial part in new treatments through phytocannabinoids by functioning as a cannabidiol receptor. This review article aims to comprehend and disseminate more information about the plant as a potential treatment for neuropathic pain. Forty-six studies were included from 2,619 identified articles. Articles published in the last decade, in full, with open access, and written in both Portuguese and English were utilized. Duplicate articles and abstracts not supporting the study's objective were excluded. Despite limitations in methodology and a lack of longitudinal research, the majority of studies indicated a reduction in reported pain and collateral symptoms.
Cannabis sativa has been used by peoples and cultures in various functions for thousands of years. Cannabinoids and phytocannabinoids have shown promise therapeutically. Thus, the endocannabinoid system is increasingly recognized for its role in pain modulation, playing a crucial part in new treatments through phytocannabinoids by functioning as a cannabidiol receptor. This review article aims to comprehend and disseminate more information about the plant as a potential treatment for neuropathic pain. Forty-six studies were included from 2,619 identified articles. Articles published in the last decade, in full, with open access, and written in both Portuguese and English were utilized. Duplicate articles and abstracts not supporting the study's objective were excluded. Despite limitations in methodology and a lack of longitudinal research, the majority of studies indicated a reduction in reported pain and collateral symptoms.
Palavras-chave
dor neuropática, cannabis sativa, dor crônica, sistema endocanabinóide, cannabis, neuropathic pain, cannabis sativa, chronic pain, endocannabinoid system, cannabis