Nutrientes Específicos no Retardo do Desenvolvimento e Progressão da Doença de Alzheimer: Uma Revisão Narrativa
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Data
2023-06-30
Tipo de documento
Monografia
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
Christimann, Guilherme
Orientador
Sattler, José Augusto Gasparotto
Coorientador
Resumo
A doença de Alzheimer (DA) é de caráter neurodegenerativa progressiva e fatal que afeta principalmente pessoas idosas. A DA tem-se majoritariamente pelo acúmulo de peptídeo beta-amiloide e proteína tau, que formam placas e emaranhados neurofibrilares no cérebro. Esses acúmulos prejudicam a comunicação entre as células cerebrais e levam à morte das células, resultando em perda de memória, dificuldade de raciocínio e outras disfunções cognitivas. Alterações metabólicas bem como estresse oxidativo crônico, desbalanço de citocinas pró-inflamatórias, disfunção mitocondrial, desenvolvimento de doenças crônicas não transmissíveis (DCNT) entre outros podem ser de grande influência para o desenvolvimento precoce ou até mesmo para o avanço da DA. Esta revisão narrativa de literatura teve seu alicerse nas plataformas PubMed, SciELO, MDPI e ScienceDirect, nelas foram selecionadas 151 documentos, os quais incluem ensaios clínicos, pré-clinicos, revisões sistemáticas, estudos de intervenção, análises e estudos prospectivos observacionais. As pluralidades desta pesquisa apontam que é possível retardardar o declínio cognitivo e, também atrasar o ínico da patologia de Alzheimer. Entretanto, o possível papel de nutricionista pesquisadores seria retardar este avanço, através do desenvolvimento de um protocolo magistral com as mais próximas e exatas quantidades de determinados nutrientes responsáveis pela proteção neurocognitiva.
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that mainly affects elderly people. AD is mostly caused by the accumulation of betaamyloid peptide and tau protein, which form plaques and neurofibrillary tangles in the brain. These accumulations impair communication between brain cells and lead to cell death, resulting in memory loss, impaired thinking, and other cognitive dysfunctions. Metabolic alterations as well as chronic oxidative stress, imbalance of pro-inflammatory cytokines, mitochondrial dysfunction, development of chronic noncommunicable diseases (NCDs) among others can be of great influence for the early development or even for the advancement of AD. This narrative literature review was based on PubMed, SciELO, MDPI and ScienceDirect platforms, from which 151 documents were selected, which include clinical, preclinical, systematic reviews, intervention studies, analyzes and prospective observational studies. The pluralities of this research indicate that it is possible to delay cognitive decline and also delay the onset of Alzheimer's pathology. However, the possible role of research nutritionists would be to delay this advance, through the development of a masterful protocol with the closest and most exact amounts of certain nutrients responsible for neurocognitive protection.
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that mainly affects elderly people. AD is mostly caused by the accumulation of betaamyloid peptide and tau protein, which form plaques and neurofibrillary tangles in the brain. These accumulations impair communication between brain cells and lead to cell death, resulting in memory loss, impaired thinking, and other cognitive dysfunctions. Metabolic alterations as well as chronic oxidative stress, imbalance of pro-inflammatory cytokines, mitochondrial dysfunction, development of chronic noncommunicable diseases (NCDs) among others can be of great influence for the early development or even for the advancement of AD. This narrative literature review was based on PubMed, SciELO, MDPI and ScienceDirect platforms, from which 151 documents were selected, which include clinical, preclinical, systematic reviews, intervention studies, analyzes and prospective observational studies. The pluralities of this research indicate that it is possible to delay cognitive decline and also delay the onset of Alzheimer's pathology. However, the possible role of research nutritionists would be to delay this advance, through the development of a masterful protocol with the closest and most exact amounts of certain nutrients responsible for neurocognitive protection.
Palavras-chave
Alzheimer, Compostos Bioativos, Vitaminas, Micronutrientes, Carotenoides, Antocianinas