Uso de peçonha de serpentes e escorpiões como possíveis fármacos para o tratamento do câncer de mama
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Data
2024-06
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
MOREIRA, Ana Flávia Batista
PAULA, Gabrielle Caroline dos Santos de
SOUZA, Maiara da Silva Gomes de
NIQUINI, Talita Iasmim da Costa
Orientador
MACHADO, Daniela Sanches
Coorientador
SIMOES, Renata Toscano
Resumo
O câncer de mama é uma das neoplasias mais frequentes e fatais, principalmente entre as mulheres. Pesquisas têm evidenciado que essas toxinas podem exercer efeitos antitumorais, como a inibição da proliferação celular, indução de apoptose e redução da migração celular em células cancerígenas. Entre os componentes estudados estão fosfolipase A2 e “toxinas de três dedos” das serpentes, além de enzimas e peptídeos de baixo peso molecular de escorpiões, que mostram potencial promissor. O objetivo do presente estudo foi realizar uma revisão da literatura científica para investigar o potencial terapêutico das toxinas provenientes de serpentes e escorpiões em combate ao câncer de mama. Para isso foi realizada uma revisão integrativa da literatura, através da consulta de artigos científicos, teses, dissertações e dados epidemiológicos. As fontes utilizadas foram as bases de dados Google Acadêmico, PubMed, Teses USP, INCA.GOV, Scielo, OPAs e Instituto Butantan, abrangendo publicações de 2014 a 2024. Foram utilizadas como palavras-chave “breast cancer and snake venom” “cancer and snake venom” “veneno de escorpião para o tratamento de câncer”. Conclui-se que, embora mais estudos sejam necessários, as peçonhas de serpentes e escorpiões oferecem uma promissora fonte de compostos bioativos que podem ser explorados para tratamentos mais eficazes e menos invasivos contra o câncer de mama.
Breast cancer is one of the most common and fatal neoplasms, especially among women. Research has shown that these proteins can exert antitumor effects, such as inhibiting cellular nutrition, inducing apoptosis and reducing cell migration in cancer cells. Among the components studied are phospholipase A2 and “three-finger toxins” from snakes, as well as enzymes and low molecular weight peptides from scorpions, which show promising potential. The objective of the present study was to carry out a review of the scientific literature to investigate the therapeutic potential of toxins from snakes and scorpions in the fight against breast cancer. To this end, an integrative review of the literature was carried out, through consultation of scientific articles, theses, dissertations and epidemiological data. The sources used were the databases Google Scholar, PubMed, Teses USP, INCA.GOV, Scielo, OPAs and Instituto Butantan, covering publications from 2014 to 2024. The keywords “breast cancer and snake venom” were used. cancer and snake venom” “scorpion venom for the treatment of cancer”. It is concluded that, although more studies are needed, snake and scorpion venoms offer a promising source of bioactive compounds that can be explored for more effective and less invasive treatments against breast cancer.
Breast cancer is one of the most common and fatal neoplasms, especially among women. Research has shown that these proteins can exert antitumor effects, such as inhibiting cellular nutrition, inducing apoptosis and reducing cell migration in cancer cells. Among the components studied are phospholipase A2 and “three-finger toxins” from snakes, as well as enzymes and low molecular weight peptides from scorpions, which show promising potential. The objective of the present study was to carry out a review of the scientific literature to investigate the therapeutic potential of toxins from snakes and scorpions in the fight against breast cancer. To this end, an integrative review of the literature was carried out, through consultation of scientific articles, theses, dissertations and epidemiological data. The sources used were the databases Google Scholar, PubMed, Teses USP, INCA.GOV, Scielo, OPAs and Instituto Butantan, covering publications from 2014 to 2024. The keywords “breast cancer and snake venom” were used. cancer and snake venom” “scorpion venom for the treatment of cancer”. It is concluded that, although more studies are needed, snake and scorpion venoms offer a promising source of bioactive compounds that can be explored for more effective and less invasive treatments against breast cancer.
Palavras-chave
terapia antiofidica, snake venom, scorpion venom, breast cancer, treatment