Electrostimulation of the auricular branch vagus nerve (AVNSn) prolongs physical exercise induced analgesia in mice peripheral inflammation

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dc.contributor.advisorMartins, Daniel
dc.contributor.authorDutra, Aline
dc.coverage.spatialPalhoçapt_BR
dc.date.accessioned2021-07-14T16:27:39Z
dc.date.available2021-07-14T16:27:39Z
dc.date.issued2021
dc.description.abstractThe present study sought to evaluate the analgesic effect caused by electro-stimulation of auricular branch of the vagus nerve (AVNSn) associated with physical exercise in mice with peripheral inflammation.This is a non-clinical experimental study, 64 Swiss male mices (35-40 g) were subjected to the Complete Freund Adjvant intraplantar injection procedure (CFA) and then treatment with AVNSn in the left ear for different times and/or swimming for 30 minutes. The Animals were allocated to the following groups: Control, Swimming, AVNSn 10 minutes, AVNSn 20 minutes, AVNSn 30 minutes, swimming + AVNSn 10 minutes, swimming + AVNSn 20 minutes and swimming + AVNSn 30 minutes for 4 consecutive days. After the treatment the animals were submitted for evaluation of mechanical hyperalgesia by the von Frey test (0.6 g), evaluation of edema by Insight micrometer and leg surface temperature by Thermal imager (Testo 880®). It was observed that the swimming group + AVNSn 20 minutes presented a signitifcative reduction (p < 0.01) of the pain on the first day and on the fourth day, the swimming group + AVNSn 30 minutes (p < 0.001). These data demonstrate that AVNSn prolongs exercise-induced analgesia in a model of persistent inflammatory pain.en
dc.format.extent20 f.pt_BR
dc.identifier.urihttps://repositorio.animaeducacao.com.br/handle/ANIMA/14556
dc.language.isoenpt_BR
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Brasil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectInflammationpt_BR
dc.subjectVagus nervept_BR
dc.subjectPhysical exercisept_BR
dc.titleElectrostimulation of the auricular branch vagus nerve (AVNSn) prolongs physical exercise induced analgesia in mice peripheral inflammationpt_BR
dc.typeArtigo Científicopt_BR
local.author.cursoFisioterapiapt_BR
local.author.unidadeUNISUL / Pedra Brancapt_BR
local.dateissued.semester1pt_BR
local.rights.policyAcesso fechadopt_BR
local.subject.areaCiências da Saúdept_BR
local.subject.areaanimaCiências Biológicas & da Saúdept_BR

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