People living with HIV on ART have accurate perception of lipodystrophy signs: a cross‑sectional study

Alencastro, Paulo Ricardo; Barcellos, Nêmora T; Wolff, Fernando H; Ikeda, Maria Letícia Rodrigues; Schuelter-Trevisol, Fabiana; Brandão, Ajácio M B; Fuchs, Sandra C

People living with HIV on ART have accurate perception of lipodystrophy signs: a cross‑sectional study

dc.contributor.author	Alencastro, Paulo Ricardo
dc.contributor.author	Barcellos, Nêmora T
dc.contributor.author	Wolff, Fernando H
dc.contributor.author	Ikeda, Maria Letícia Rodrigues
dc.contributor.author	Schuelter-Trevisol, Fabiana
dc.contributor.author	Brandão, Ajácio M B
dc.contributor.author	Fuchs, Sandra C
dc.coverage.spatial	Reino Unido	pt_BR
dc.date.accessioned	2019-07-26T21:29:26Z
dc.date.accessioned	2020-11-26T17:33:11Z
dc.date.available	2019-07-26T21:29:26Z
dc.date.available	2020-11-26T17:33:11Z
dc.date.issued	2017	pt_BR
dc.description.abstract	BACKGROUND: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution changes. Although several methods have been developed, there is no gold standard for characterization of LA and LH, or mixed forms. This study aimed to compare self-reported signs of lipodystrophy with objective measures by skinfolds and circumferences, and to evaluate the prevalence of lipoatrophy (LA) and lipohypertrophy (LH) among subjects living with HIV/AIDS on ART. METHODS: A cross-sectional study enrolled participants living with HIV/AIDS receiving ART, aged 18 years or older from an outpatient health care center, in Southern Brazil. Self-reported body fat enlargement in the abdomen, chest or breasts, and dorsocervical fat pad were used to determine LH, while LA was identified by self-reported fat wasting of the face, neck, legs, arms or buttocks. Measurements were obtained with a scientific caliper for infraorbital, buccal, and submandibular skinfolds, and using an inelastic tape to measure circumferences of waist, hip, neck, and arm. LH and LA were established by the presence of at least one self-reported sign. RESULTS: Comparisons of self-reported signs with objective measurements for men and women were carried out in 815 participants on ART, out of 1240 participants with HIV infection. Self-report of decreased facial fat and sunken cheeks was associated with lower infraorbital, buccal, and submandibular skinfolds. Participants who reported buffalo hump had, on average, greater neck circumference, as well as those who have increased waist circumference also reported abdominal enlargement, but no buttock wasting. Men were most commonly affected by lipoatrophy (73 vs. 53%; P < 0.001), and women by lipohypertrophy (79 vs. 56%; P < 0.001). CONCLUSION: In conclusion, self-reported signs of lipodystrophy and lipoatrophy are prevalent, differ by gender, and are associated with objective measurements in people living with HIV/AIDS.	pt_BR
dc.description.sponsorship	Não há.	pt_BR
dc.format.extent	40	pt_BR
dc.identifier	janeiro	pt_BR
dc.identifier.issn	1756-0500	pt_BR
dc.identifier.uri	https://repositorio.animaeducacao.com.br/handle/ANIMA/2612
dc.language.iso	en_US	pt_BR
dc.relation.ispartofseries	10	pt_BR
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/br/	*
dc.subject	HIV	pt_BR
dc.subject	AIDS	pt_BR
dc.subject	Lipodystrophy	pt_BR
dc.subject	Lypohypertrophy	pt_BR
dc.subject	Lipoatrophy	pt_BR
dc.title	People living with HIV on ART have accurate perception of lipodystrophy signs: a cross‑sectional study	pt_BR
dc.type	Artigo de Periodico	pt_BR
local.affiliation.ies	Unisul
local.author.curso	Produção Científica	pt_BR
local.author.unidade	Ânima	pt_BR
local.rights.policy	Acesso aberto	pt_BR
local.subject.area	Ciências da Saúde	pt_BR
local.subject.areaanima	Ciências Humanas	pt_BR