Hereditariedade e genética do câncer de mama: como a genética e a hereditariedade colaboram para o desenvolvimento do câncer de mama em mulheres jovens
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
SANTOS, Gabryela Rayra dos
Orientador
CARVALHO, Rafael Leite de
Coorientador
Resumo
INTRODUÇÃO: O câncer de mama é uma neoplasia comum em mulheres globalmente, apresentando desafios significativos à saúde pública. Estudos recentes têm se concentrado na compreensão dos fatores genéticos e hereditários relacionados ao desenvolvimento dessa doença. A identificação de genes como BRCA1 e BRCA2 revolucionou a compreensão genética do câncer de mama, impactando estratégias de prevenção e tratamento. OBJETIVOS: O objetivo geral deste estudo foi investigar o papel da hereditariedade e da genética no câncer de mama em mulheres jovens, visando compreender fatores de risco bem como, também, para analisar a influência dos fatores genéticos e dos genes associados ao câncer de mama e investigar a mutação genética desses como um fator para a hereditariedade. METODOLOGIA: Foi realizada uma revisão sistemática da literatura em bases de dados como PubMed, SciELO e Web of Science, utilizando termos relacionados ao câncer de mama, mulheres jovens, hereditariedade e genética. Foram selecionados, principalmente, estudos publicados nos últimos 10 anos, com foco em mulheres jovens diagnosticadas com câncer de mama. CONCLUSÃO: O estudo ressalta o aumento dos casos de câncer de mama em mulheres jovens e sua relação com prognósticos desfavoráveis, destacando a importância da detecção precoce e da conscientização sobre os fatores de risco. As mutações genéticas, especialmente em genes herdados, têm impacto significativo na predisposição ao câncer de mama em mulheres mais jovens, sugerindo a necessidade de estratégias preventivas e terapêuticas direcionadas a esse grupo populacional.
INTRODUCTION: Breast cancer is a common neoplasm in women globally, presenting significant challenges to public health. Recent studies have focused on understanding the genetic and hereditary factors related to the development of this disease. The identification of genes such as BRCA1 and BRCA2 has revolutionized the genetic understanding of breast cancer, impacting prevention and treatment strategies. OBJECTIVES: The general objective of this study was to investigate the role of heredity and genetics in breast cancer in young women, aiming to understand risk factors as well as to analyze the influence of genetic factors and genes associated with breast cancer and investigate the genetic mutation of these as a factor in heredity. METHODOLOGY: A systematic review of the literature was carried out in databases such as PubMed, SciELO and Web of Science, using terms related to breast cancer, young women, heredity and genetics. Mainly, studies published in the last 10 years were selected, focusing on young women diagnosed with breast cancer. CONCLUSION: The study highlights the increase in cases of breast cancer in young women and its relationship with unfavorable prognoses, highlighting the importance of early detection and awareness of risk factors. Genetic mutations, especially in inherited genes, have a significant impact on the predisposition to breast cancer in younger women, suggesting the need for preventive and therapeutic strategies aimed at this population group.
INTRODUCTION: Breast cancer is a common neoplasm in women globally, presenting significant challenges to public health. Recent studies have focused on understanding the genetic and hereditary factors related to the development of this disease. The identification of genes such as BRCA1 and BRCA2 has revolutionized the genetic understanding of breast cancer, impacting prevention and treatment strategies. OBJECTIVES: The general objective of this study was to investigate the role of heredity and genetics in breast cancer in young women, aiming to understand risk factors as well as to analyze the influence of genetic factors and genes associated with breast cancer and investigate the genetic mutation of these as a factor in heredity. METHODOLOGY: A systematic review of the literature was carried out in databases such as PubMed, SciELO and Web of Science, using terms related to breast cancer, young women, heredity and genetics. Mainly, studies published in the last 10 years were selected, focusing on young women diagnosed with breast cancer. CONCLUSION: The study highlights the increase in cases of breast cancer in young women and its relationship with unfavorable prognoses, highlighting the importance of early detection and awareness of risk factors. Genetic mutations, especially in inherited genes, have a significant impact on the predisposition to breast cancer in younger women, suggesting the need for preventive and therapeutic strategies aimed at this population group.
Palavras-chave
Câncer de mama, hereditariedade, mulheres jovens