Relação entre fluoxetina e depressão: Uma revisão integrativa de literatura
Nenhuma Miniatura disponível
Data
2023-06-19
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
Marques, Mauri José Custódio
Orientador
Pohlmann, Lauren
Coorientador
Resumo
A depressão é uma das doenças mentais mais frequentes, caracterizada por sintomas que incapacitam e diminuem a qualidade de vida das pessoas. Assim, para tratar esta doença, foi criado o Prozac® (cloridrato de fluoxetina), droga sintética da classe dos inibidores seletivos da receptação de serotonina, sendo o antidepressivo mais utilizado no Brasil e primeira escolha no tratamento da depressão. Seus efeitos adversos mais comuns são: náuseas, diarreia, dores de cabeça e tontura. O objetivo é relacionar o uso da fluoxetina no tratamento da depressão por meio de uma revisão de literatura. As bases de dados utilizadas foram Scientific Eletronic Library Online (SciELO), Google Acadêmico e PERIÓDICOS CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). Os descritores utilizados foram “fluoxetina”, “depressão” e “efeitos adversos”. Os critérios de inclusão foram publicações que abordavam sobre a depressão associada ao uso de fluoxetina e seus eventos adversos. Excluíram-se os estudos que não condizem com os descritores e ao escopo do estudo, pois não havia correlação com o trabalho. Utilizaram-se artigos entre os anos de 2013 e 2023. Este estudo evidenciou as principais manifestações da depressão e o uso da fluoxetina com os principais efeitos clínicos, farmacocinética, farmacodinâmica, efeitos adversos e contraindicações. Concluiu-se que o tratamento para depressão com a fluoxetina se mostrou eficaz e muito utilizado entre os brasileiros adultos com grande potencial para novos estudos.
Depression is one of the most common mental illnesses, characterized by symptoms that disable people and reduce their quality of life. Thus, to treat this disease, Prozac® (fluoxetine hydrochloride) was created, a synthetic drug from the class of selective serotonin reuptake inhibitors, being the most used antidepressant in Brazil and the first choice in the treatment of depression. Its most common adverse effects are: nausea, diarrhea, headaches and dizziness. The objective is to relate the use of fluoxetine in the treatment of depression through a literature review. The databases used were Scientific Electronic Library Online (SciELO), Google Scholar and PERIÓDICOS CAPES (Coordination for the Improvement of Higher Education Personnel). The descriptors used were “fluoxetine”, “depression” and “adverse effects”. Inclusion criteria were publications that addressed depression associated with the use of fluoxetine and its adverse events. Studies that did not match the descriptors and scope of the study were excluded, as there was no correlation with the work. Articles between the years 2013 and 2023 were used. This study showed the main manifestations of depression and the use of fluoxetine with the main clinical effects, pharmacokinetics, pharmacodynamics, adverse effects and contraindications. It was concluded that the treatment for depression with fluoxetine proved to be effective and widely used among Brazilian adults with great potential for further studies.
Depression is one of the most common mental illnesses, characterized by symptoms that disable people and reduce their quality of life. Thus, to treat this disease, Prozac® (fluoxetine hydrochloride) was created, a synthetic drug from the class of selective serotonin reuptake inhibitors, being the most used antidepressant in Brazil and the first choice in the treatment of depression. Its most common adverse effects are: nausea, diarrhea, headaches and dizziness. The objective is to relate the use of fluoxetine in the treatment of depression through a literature review. The databases used were Scientific Electronic Library Online (SciELO), Google Scholar and PERIÓDICOS CAPES (Coordination for the Improvement of Higher Education Personnel). The descriptors used were “fluoxetine”, “depression” and “adverse effects”. Inclusion criteria were publications that addressed depression associated with the use of fluoxetine and its adverse events. Studies that did not match the descriptors and scope of the study were excluded, as there was no correlation with the work. Articles between the years 2013 and 2023 were used. This study showed the main manifestations of depression and the use of fluoxetine with the main clinical effects, pharmacokinetics, pharmacodynamics, adverse effects and contraindications. It was concluded that the treatment for depression with fluoxetine proved to be effective and widely used among Brazilian adults with great potential for further studies.
Palavras-chave
Fluoxetina, Depressão, Efeitos adversos