Mimosa caesalpiniifolia, nova possibilidade para remediar medicamentos de primeira linha no tratamento da candidíase vulvovaginal recorrente ocasionada por candida não albicans.
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Data
2020-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
CÂMARA, Sarepta Smirna de Góis
Orientador
FERREIRA, Caio Fernando Martins
Coorientador
Resumo
A candidíase vulvovaginal (CVV) é um importante problema na saúde da mulher,
com ocorrência em 75% em idade fértil na qual 5% transformam-se em recorrentes.
Por não apresentar sinais e sintomas patognomônicos da doença o seu diagnóstico é
constantemente executado de maneira empírica, com prescrição precipitada ou a
automedicação, sendo estes os principais motivos de resistência fúngica
medicamentosa e impasses no tratamento, principalmente quando refere-se a C.
krusei e algumas cepas da C. glabrata, responsáveis por 33% dos casos, devendo ter
o método terapêutico reavaliado. A Mimosa caesalpiniifolia popularmente chamada de
“unha-de-gato” é uma árvore nativa da região nordeste brasileira, que demostrou ser
mais eficaz sobre a C. glabrata e C. krusei, por concentrar maior porção de
flavonoides, tendo ação antifúngica presente em 70% da folha da planta. O objetivo
geral do estudo é apresentar uma nova alternativa de tratamento para a candidíase
vulvovaginal ocasionada por espécies de Candida não albicans, por meio de revisão
sistemática. Mais especificadamente intenciona: ressaltar estudos acerca da atividade
antifúngica de extratos e frações obtidas em diferentes partes da planta e esclarecer
sobre a importância de um bom diagnóstico clínico em pacientes com candidíase
vulvovaginal recorrente. O artigo foi elaborado através de revisão de literatura por
consulta eletrônica, utilizando as bases de dados: Scientific Eletronic Library Online
(SCIELO), PubMed e Google acadêmico. A avaliação da capacidade microbiológica
da M. caesalpiniifolia ainda necessita de mais estudos levando em consideração as
propriedades fitoquímicas da planta, de modo a encontrar um tratamento simples, de
menor custo e mais específico para a candidíase vaginal recorrente por C. não
albicans.
Vulvovaginal candidiasis (CVV) is an important problem in women's health, occurring in 75% of childbearing age in which 5% become recurrent. As it does not present pathognomonic signs and symptoms of the disease, its diagnosis is constantly performed in an empirical manner, with hasty prescription or self-medication, these being the main reasons for fungal drug resistance and treatment impasses, especially when referring to C. krusei and some strains of C. glabrata, responsible for 33% of cases, and the therapeutic method must be reassessed. Mimosa caesalpiniifolia popularly called "cat's claw" is a tree native to the northeast of Brazil, which has been shown to be more effective on C. glabrata and C. krusei, as it concentrates a larger portion of flavonoids, having antifungal action present in 70 % of plant leaf. The general objective of the study is to present a new treatment alternative for vulvovaginal candidiasis caused by non-albicans Candida species, through a systematic review. More specifically, it intends to: highlight studies on the antifungal activity of extracts and fractions obtained in different parts of the plant and clarify the importance of a good clinical diagnosis in patients with recurrent vulvovaginal candidiasis. The article was prepared through a literature review by electronic consultation, using the following databases: Scientific Electronic Library Online (SCIELO), PubMed and Google academic. The evaluation of the microbiological capacity of M. caesalpiniifolia still needs further studies taking into account the phytochemical properties of the plant, in order to find a simple, lower cost and more specific treatment for recurrent vaginal candidiasis by C. non albicans.
Vulvovaginal candidiasis (CVV) is an important problem in women's health, occurring in 75% of childbearing age in which 5% become recurrent. As it does not present pathognomonic signs and symptoms of the disease, its diagnosis is constantly performed in an empirical manner, with hasty prescription or self-medication, these being the main reasons for fungal drug resistance and treatment impasses, especially when referring to C. krusei and some strains of C. glabrata, responsible for 33% of cases, and the therapeutic method must be reassessed. Mimosa caesalpiniifolia popularly called "cat's claw" is a tree native to the northeast of Brazil, which has been shown to be more effective on C. glabrata and C. krusei, as it concentrates a larger portion of flavonoids, having antifungal action present in 70 % of plant leaf. The general objective of the study is to present a new treatment alternative for vulvovaginal candidiasis caused by non-albicans Candida species, through a systematic review. More specifically, it intends to: highlight studies on the antifungal activity of extracts and fractions obtained in different parts of the plant and clarify the importance of a good clinical diagnosis in patients with recurrent vulvovaginal candidiasis. The article was prepared through a literature review by electronic consultation, using the following databases: Scientific Electronic Library Online (SCIELO), PubMed and Google academic. The evaluation of the microbiological capacity of M. caesalpiniifolia still needs further studies taking into account the phytochemical properties of the plant, in order to find a simple, lower cost and more specific treatment for recurrent vaginal candidiasis by C. non albicans.
Palavras-chave
candidíase vulvovaginal, candida, mimosa caesalpiniifolia