Potential Psychotropic Drug Interactions among Drug-dependent People

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dc.contributor.authorNascimento, Diego Zapelini do
dc.contributor.authorMarques, Gabriela Moreno
dc.contributor.authorSchuelter-Trevisol, Fabiana
dc.coverage.spatialUnited Kingdompt_BR
dc.date.accessioned2020-12-02T13:36:27Z
dc.date.accessioned2021-08-04T15:39:32Z
dc.date.available2020-12-02T13:36:27Z
dc.date.available2021-08-04T15:39:32Z
dc.date.issued2020pt_BR
dc.description.abstractUsing psychiatric drugs to treat drug dependence and its comorbidities is very common. The objective of this study was to analyze the interactions between prescribed drugs for patients treated at a specialized mental health-care center for persons who use drugs, located in the state of Santa Catarina, Brazil. A cross-sectional study was conducted on secondary data collected from 2010 to 2018. We reviewed the medical records of patients aged 18 years or older who took psychotropic drugs and had any type of substance dependence. The analysis of psychotropic drug interactions was conducted in three databases: Medscape, Drug Interactions Checker, and Micromedex. We included 1,022 of the 2,322 patients attending the care center during the study period. Psychotropic drug interactions were found in 779 (76.4%) study participants, and they presented 2,292 (100%) interactions, out of which 136 (6.0%) had minor clinical risk, 537 (23.4%) had moderate risk, and 1,619 (70.6%) had major risk for the patient, totaling 172 incompatible combinations between two psychotropic drugs. Of the total number of interactions, 128 were pharmacokinetic and 44 were pharmacodynamic. The high number of psychotropic drug interactions is a serious public health issue. Psychopharmacological treatment should be carefully addressed to be safe for the patient.pt_BR
dc.description.sponsorshipNão hápt_BR
dc.format.extent1-9pt_BR
dc.identifier.issn21599777pt_BR
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/02791072.2020.1849878pt_BR
dc.identifier.urihttps://repositorio.animaeducacao.com.br/handle/ANIMA/15086
dc.language.isoen_USpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectDrug interactionspt_BR
dc.subjectdrugrelated side effects and adverse reactionspt_BR
dc.subjectsubstance-related disorderspt_BR
dc.subjectmental healthpt_BR
dc.subjectpharmacovigilancept_BR
dc.titlePotential Psychotropic Drug Interactions among Drug-dependent Peoplept_BR
dc.typeArtigo de Periodicopt_BR
local.affiliation.iesUnisul
local.author.cursoProdução Científicapt_BR
local.author.unidadeÂnimapt_BR
local.rights.policyAcesso embargadopt_BR
local.subject.areaCiências da Saúdept_BR
local.subject.areaanimaCiências Humanaspt_BR

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