Epigenética e a alergia ao leite de vaca : uma revisão bibliografica
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Data
2023-12
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Artigo Científico
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Acesso fechado
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Autores
MARIANO, Roberta Barbosa
Orientador
LICKS, Francieli
Coorientador
Resumo
Introdução: A alergia ao leite de vaca tem sido um achado muito comum na prática pediátrica em bebês e crianças e o desenvolvimento dessa alergia ainda é de origem desconhecida. Atualmente vem surgindo alguns estudos que ligam a alergia ao leite de vaca á influência da epigenética. A epigenética estuda como fatores ambientais podem causar alterações hereditárias sem que sejam alteradas as sequencias de DNA alguns mecanismos epigenéticos e a metilação do DNA é um deles. Estudos sugerem que a metilação do DNA tem influência nas células Tregs, causando uma resposta exagerada das células Th2 e essa estimulação exagerada acaba ocasionando a alergia ao leite de vaca. Métodos: Foi realizada uma pesquisa no site Pubmed e feita uma busca de artigos relacionados ao tema. Resultados: Após a busca foi elaborada a seleção dos artigos pertinentes ao assunto. Conclusão; Nessa revisão é apresentada algumas evidências cientificas que trazem como a metilação do DNA pode estar envolvida na ALV e o envolvimento de Foxp3 na tolerancia oral em crianças com alergia ao leite de vaca, ou seja, ao adquirir tolerância se tem um envolvimento de regulação epignética a desmetilação do DNA. Certamente estes estudos trazem possibilidades de novas ferramentas na abordagem e tratamento deste tipo de alergia.
Cow's milk allergy has been a very common finding in pediatric practice in infants and children and the development of this allergy is still of unknown origin. Currently, there are some studies that link cow's milk allergy to the influence of epigenetics. Epigenetics studies how environmental factors can cause hereditary alterations without altering DNA sequences and some epigenetic mechanisms, and DNA methylation is one of them. Studies suggest that DNA methylation has an influence on Treg cells, causing an exaggerated Th2 cell response and this exaggerated stimulation ends up causing ALV. A search was carried out on the Pubmed website and a search was made for articles related to the theme and after this search, the selection of articles relevant to the subject was elaborated. This review presents some scientific evidence on how DNA methylation may be involved in LLL and the involvement of Foxp3 in oral tolerance in children with ALV. In other words, when tolerance is acquired, there is an involvement of epigetic regulation of DNA demethylation. Certainly, these studies supplant the possibility of new tools in the approach and treatment of this type of allergy.
Cow's milk allergy has been a very common finding in pediatric practice in infants and children and the development of this allergy is still of unknown origin. Currently, there are some studies that link cow's milk allergy to the influence of epigenetics. Epigenetics studies how environmental factors can cause hereditary alterations without altering DNA sequences and some epigenetic mechanisms, and DNA methylation is one of them. Studies suggest that DNA methylation has an influence on Treg cells, causing an exaggerated Th2 cell response and this exaggerated stimulation ends up causing ALV. A search was carried out on the Pubmed website and a search was made for articles related to the theme and after this search, the selection of articles relevant to the subject was elaborated. This review presents some scientific evidence on how DNA methylation may be involved in LLL and the involvement of Foxp3 in oral tolerance in children with ALV. In other words, when tolerance is acquired, there is an involvement of epigetic regulation of DNA demethylation. Certainly, these studies supplant the possibility of new tools in the approach and treatment of this type of allergy.
Palavras-chave
epigenética, alergia ao leite