Mother-to-child transmission of HIV in the Southern Region of Santa Catarina, from 2005 to 2015: analysis of risk factors to seroconversion in newborns
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Arquivos
Data
2018
Tipo de documento
Artigo de Periodico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
Oliveira, Karen Waleska Kniphoff
Oliveira, Suzana Kniphoff
Barranco, Ana Beatriz Sanches
Hoffmann, Tamara
Duarte, Camila Soares
Nazário, Rayane Felippe
Marcon, Chaiana Esmeraldino Mendes
Schuelter-Trevisol, Fabiana
Orientador
Coorientador
Resumo
Objetivos: investigar a frequência e analisar os fatores de risco para soroconversão entre
nascidos vivos de mães soropositivas ao HIV.
Métodos: foi realizado estudo de coorte, com crianças residentes na Região Sul de Santa
Catarina. Foram usados dados secundários referentes a ficha de notificação e acompanhamento
de criança exposta ao HIV e revisão do prontuário das mães das crianças infectadas.
Participaram do estudo todos os nascidos vivos no período de 2005 a 2015 expostos
ao HIV por transmissão vertical atendidos no serviço municipal de saúde.
Resultados: houve 104 exposições ao HIV, sendo que em três casos se confirmou soroconversão
e dois foram a óbito por Aids.O aleitamento materno (RP=32,7; IC95%=10,7-
99,5); p=0,002) e o não uso de antirretroviral durante a gestação (RP=18,2; IC95%=2,0-
163,0); p=0,008) foram fatores de risco para a soroconversão.
Conclusões: a soroconversão em neonatos na Região Sul de Santa Catarina foi similar à
média nacional. Houve associação com não utilização de terapia antirretroviral durante a
gestação e aleitamento materno.
Objectives: to analyze both frequency and risk factors for seroconversion among newborns of HIV-positive mothers to HIV. Methods: a cohort study was conducted with children residing in Southern Region of Santa Catarina. Secondary data from the notification files and medical records of newborn’s mothers of infected infants were used. The participants were all the newborns from 2005 to 2015 that were exposed to HIV through vertical transmission and attended a municipal health care center. Results: there were 104 cases of infant exposure to HIV. Seroconversion was confirmed in three cases, two of them died of AIDS during the study period. Breastfeeding (PR= 32.7; CI95%= 10.7-99.5; p= 0.002) and non-use of antiretroviral drugs during pregnancy (PR=18.2; CI95%= 2.0-163.0; p= 0.008) were risk factors for HIV seroconversion. Conclusions: seroconversion rates among neonates in Southern Region of Santa Catarina were similar to the national average. Seroconversion was associated with non-use of antiretroviral therapy during pregnancy and breastfeeding.
Objectives: to analyze both frequency and risk factors for seroconversion among newborns of HIV-positive mothers to HIV. Methods: a cohort study was conducted with children residing in Southern Region of Santa Catarina. Secondary data from the notification files and medical records of newborn’s mothers of infected infants were used. The participants were all the newborns from 2005 to 2015 that were exposed to HIV through vertical transmission and attended a municipal health care center. Results: there were 104 cases of infant exposure to HIV. Seroconversion was confirmed in three cases, two of them died of AIDS during the study period. Breastfeeding (PR= 32.7; CI95%= 10.7-99.5; p= 0.002) and non-use of antiretroviral drugs during pregnancy (PR=18.2; CI95%= 2.0-163.0; p= 0.008) were risk factors for HIV seroconversion. Conclusions: seroconversion rates among neonates in Southern Region of Santa Catarina were similar to the national average. Seroconversion was associated with non-use of antiretroviral therapy during pregnancy and breastfeeding.
Palavras-chave
HIV infections, Infectious diseases transmission, vertical, Seroconversion