A fisiopatologia da leucemia Eosinofílica crônica: uma abordagem atualizada sobre um tipo de leucemia Mieloide
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Data
2023-12
Tipo de documento
Artigo Científico
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Área do conhecimento
Modalidade de acesso
Acesso aberto
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Autores
SOARES, Ana Carolina Bittencourt
Orientador
MORAES, Chaiane Mara Oliveira
Coorientador
Resumo
Introdução: A leucemia eosinofílica crônica é uma doença caracterizada por manifestação no sangue e tecidos estando associada a condições imunossupressas dos pacientes. Na fase de hematopoiese, os eosinófilos sofrem estímulos na medula por citocinas que promovem o aumento da produção de eosinófilos resultando no crescimento granulócito-macrófagos, esses estímulos recebidos são liberados pelos linfócitos T, com manifestação em órgãos-alvo, como: pulmões, pele e trato gastrointestinal. Métodos: A base dessa pesquisa foi através de revisão de literatura em bases de dados, como: Scielo e Google Acadêmico. Para isso, o referencial teórico encontrado data entre os anos 2008 até 2013. Resultados e discussões: Antes de se atingir o estágio esinofilico crônico da leucemia, o sistema imunológico do paciente manifesta a fase de neoplasia mieoloproliferativa, no qual ocorre a doença clonal das células-tronco hematopoieticas, o aumento na proliferação de séries mieloides com maturação, leucocitose no sangue periférico, aumento da massa eritrocitária/trombocitose progredindo para fibrose medular ou formação leucêmica. Logo após as caracteristicas de etiologia da LEC no qual apontam o aumento da produção de eosinófilos pode ser vinculado, também, a condições alérgicas, infecciosas, inflamatórias, medicamentosas e exposição a tóxicos. Conclusão: O trabalho apresentado iniciou um esclarecimento acerca da forma como a leucemia eosinofílica se manifesta, principalmente quando acomete pacientes imunossuprimidos. O descontrole medular previsto na patologia afeta fisicamente os pacientes contribuindo para um avanço da enfermidade, dividida, esta, em fases que causam alterações genéticas e hematológicas, bem como com evolução variada.
Introduction: Chronic eosinophilic leukemia is a disease characterized by manifestation in blood and tissues and associated with immunosuppressed conditions of patients. In the hematopoiesis phase, eosinophils are stimulated in the bone marrow by cytokines that promote an increase in the production of eosinophils resulting in granulocyte-macrophage growth, these received stimuli are released by T lymphocytes, with manifestation in target organs, such as: lungs, skin and gastrointestinal tract. Methods: The basis of this research was through a literature review in databases such as Scielo and Google Scholar. For this, the theoretical framework found dates between the years 2008 and 2013. Results and discussions: Before reaching the chronic esinophilic stage of leukemia, the patient's immune system manifests the myeloproliferative neoplasia phase, in which hematopoietic stem cell clonal disease occurs, increased proliferation of maturing myeloid series, leukocytosis in peripheral blood, increased erythrocyte mass/thrombocytosis progressing to medullary fibrosis or leukemic formation. Soon after the etiology characteristics of LEC in which they point out, the increase in the production of eosinophils can also be linked to allergic, infectious, inflammatory, drug conditions and exposure to toxic substances. Conclusion: The this study initiated a clarification about how eosinophilic leukemia manifests itself, especially when it affects immunosuppressed patients. The spinal cord lack of control predicted in the pathology physically affects the patients, contributing to an advancement of the disease, which is divided into phases that cause genetic and hematological alterations, as well as with varied evolution.
Introduction: Chronic eosinophilic leukemia is a disease characterized by manifestation in blood and tissues and associated with immunosuppressed conditions of patients. In the hematopoiesis phase, eosinophils are stimulated in the bone marrow by cytokines that promote an increase in the production of eosinophils resulting in granulocyte-macrophage growth, these received stimuli are released by T lymphocytes, with manifestation in target organs, such as: lungs, skin and gastrointestinal tract. Methods: The basis of this research was through a literature review in databases such as Scielo and Google Scholar. For this, the theoretical framework found dates between the years 2008 and 2013. Results and discussions: Before reaching the chronic esinophilic stage of leukemia, the patient's immune system manifests the myeloproliferative neoplasia phase, in which hematopoietic stem cell clonal disease occurs, increased proliferation of maturing myeloid series, leukocytosis in peripheral blood, increased erythrocyte mass/thrombocytosis progressing to medullary fibrosis or leukemic formation. Soon after the etiology characteristics of LEC in which they point out, the increase in the production of eosinophils can also be linked to allergic, infectious, inflammatory, drug conditions and exposure to toxic substances. Conclusion: The this study initiated a clarification about how eosinophilic leukemia manifests itself, especially when it affects immunosuppressed patients. The spinal cord lack of control predicted in the pathology physically affects the patients, contributing to an advancement of the disease, which is divided into phases that cause genetic and hematological alterations, as well as with varied evolution.
Palavras-chave
leucemia eosinofilica aguda, sindrome hipereosinofilica, citocinas, eosinoflia, ativação de macrofagos