Estudo do impacto da ativação imune materna sobre o comportamento da prole após sepse na vida adulta

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dc.contributor.advisorFortunato, Jucélia Jeremias
dc.contributor.authorGomes, Thainá Cidreira dos Santos
dc.contributor.authorAbrahão, Sabini
dc.coverage.spatialTubarãopt_BR
dc.date.accessioned2022-12-06T14:00:17Z
dc.date.available2022-12-06T14:00:17Z
dc.date.issued2022
dc.description.abstractSepsis is a life-threatening complex organ dysfunction resulting from dysregulated host responses to infection. This study aimed to evaluate whether maternal immune activation in the gestational period can activate neuroinflammation factors in offspring in adulthood after polymicrobial sepsis, and result in protection against behavioral changes. The study was performed on the offspring of sows exposed to LPS or saline in the prenatal period. Upon completing 60 days, sepsis was induced by CLP or sham. The animals were then divided into 8 groups: SAL+SHAM female and male, SAL+CLP female and male, LPS+SHAM female and male, LPS+CLP female and male. The behavior of the groups in the open field were analyzed in the parameters grooming, defecation, rearing and in forced swimming the parameters swimming, immobility, diving. The LPS+CLP groups, In view of the results obtained, it can be said that maternal immune activation associated with systemic inflammation induced by sepsis produced ambivalent results, resulting in anxious, depressive or stressed behaviors in some groups and improved memory in others, evidencing the beneficial effect of conditioning.en
dc.format.extent57 f.pt_BR
dc.identifier.urihttps://repositorio.animaeducacao.com.br/handle/ANIMA/27293
dc.language.isoptpt_BR
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Brasil
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/
dc.subjectSepsept_BR
dc.subjectAtivação imunematernapt_BR
dc.subjectComportamentopt_BR
dc.titleEstudo do impacto da ativação imune materna sobre o comportamento da prole após sepse na vida adultapt_BR
dc.typeArtigo Científicopt_BR
local.author.cursoMedicinapt_BR
local.author.unidadeTubarão / UNISULpt_BR
local.contributor.coadvisorPetronilho, Fabricia
local.dateissued.semester2pt_BR
local.modalidade.estudoPresencialpt_BR
local.rights.policyAcesso embargadopt_BR
local.subject.areaCiências da Saúdept_BR
local.subject.areaanimaCiências Médicaspt_BR

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