Anemia Aplásica: uma revisão de literatura.
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
CHAGAS, Jane Maria Bezerra
GOMES, Joelson da Silva
Orientador
FERREIRA, Sarah de Sousa
Coorientador
Resumo
A anemia aplásica adquirida (AAA) é uma doença autoimune caracterizada por pancitopenia na medula óssea e no sangue periférico. Além disso, o mecanismo mais comum da AAA é um comprometimento do sistema imunológico, levando ao aumento da apoptose das células pro- genitoras. O objetivo deste estudo foi apresentar artigos científicos atualizados sobre a doença. Para tanto foram encontrados quatorze artigos com dados dos anos 2001 – 2022, nos seguintes bancos de dados: Pubmed, Scielo e Google Acadêmico. O estudo mostrou que a doença envolve defeitos quantitativos no número de células-tronco e anormalidades qualitativas na função des- sas células, e que a atividade de diversos fatores celulares e moleculares pode danificar as cé- lulas hematopoiéticas e a matriz protetora dessas células. Nesta doença, tanto as células-tronco hematopoiéticas quanto as células estromais mesenquimais são danificadas, o que está associ- ado à hematopoiese prejudicada e à redução das células hematopoiéticas. Portanto, as citocinas inflamatórias aumentam, alterando a proporção de linfócitos T e levando à progressão da doença.
Acquired aplastic anemia (AAA) is an autoimmune disease characterized by pancytopenia in the bone marrow and peripheral blood. Furthermore, the most common mechanism of AAA is an impairment of the immune system, leading to increased apoptosis of progenitor cells. The objective of this study was to present updated scientific articles on the disease. To this end, fourteen articles with data from the years 2001 – 2022 were found in the following databases: Pubmed, Scielo and Google Scholar. The study showed that the disease involves quantitative defects in the number of stem cells and qualitative abnormalities in the function of these cells, and that the activity of several cellular and molecular factors can damage hematopoietic cells and the protective matrix of these cells. In this disease, both hematopoietic stem cells and mesenchymal stromal cells are damaged, which is associated with impaired hematopoiesis and a reduction in hematopoietic cells. Therefore, inflammatory cytokines increase, altering the proportion of T lymphocytes and leading to disease progression.
Acquired aplastic anemia (AAA) is an autoimmune disease characterized by pancytopenia in the bone marrow and peripheral blood. Furthermore, the most common mechanism of AAA is an impairment of the immune system, leading to increased apoptosis of progenitor cells. The objective of this study was to present updated scientific articles on the disease. To this end, fourteen articles with data from the years 2001 – 2022 were found in the following databases: Pubmed, Scielo and Google Scholar. The study showed that the disease involves quantitative defects in the number of stem cells and qualitative abnormalities in the function of these cells, and that the activity of several cellular and molecular factors can damage hematopoietic cells and the protective matrix of these cells. In this disease, both hematopoietic stem cells and mesenchymal stromal cells are damaged, which is associated with impaired hematopoiesis and a reduction in hematopoietic cells. Therefore, inflammatory cytokines increase, altering the proportion of T lymphocytes and leading to disease progression.
Palavras-chave
Anemia aplásica, Células estromais mesenquimais, Células-tronco hematopoiéticas, Pancitopenia