Zebrafish como modelo experimental de estudo em substâncias psicoativas: uma revisão literária
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Data
2023-06-29
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
Oliveira, Vitória Karolyne Silva
Orientador
Silva, Eldevan dos Santos
Coorientador
Resumo
O surgimento de Novas Substâncias Psicoativas tornou- se um tópico de interesse para pesquisadores, agentes políticos, profissionais de saúde e agentes de fiscalização. Essas substâncias são concebidas para imitar os efeitos farmacológicos de drogas ilícitas comuns. Um grande obstáculo na descoberta de agentes psicofarmacológicos é a dificuldade em prever como as drogas candidatas podem alterar comportamentos. Experimentos com animais são uma prática padrão para testes de hipóteses em pesquisas pré-clínicas. O zebrafish (Danio rerio) surgiu como uma espécie de escolha em estudos experimentais em farmacologia, onde é usado na triagem de drogas de alto rendimento de vários compostos psicoativos. Sendo assim, a utilidade do zebrafish na pesquisa em neurociência está crescendo rapidamente devido à sua alta homologia fisiológica e genética com humanos, facilidade de manipulação genética, comportamentos robustos e custo-benefício. Assim sendo, baseado nessas premissas, o objetivo do presente estudo foi analisar na literatura científica os resultados da utilização do zebrafish como modelo experimental no estudo de substâncias psicoativas. Tratou-se de um estudo de revisão de literatura narrativa. Por meio do presente estudo, foi possível perceber que o zebrafish pode ser usado para avaliar a toxicidade de candidatos a medicamentos em ensaios de triagem iniciais, às vezes de maneira de alto rendimento. Assim, percebe-se que complementando os roedores, o zebrafish é um organismo importante para o estudo de mecanismos de comportamento normal e patológico, bem como para o centro modelagem de doenças do sistema nervoso central desenvolvimento de medicamentos e triagem de medicamentos de alto rendimento, como no caso drogas psicoativas.
The emergence of New Psychoactive Substances has become a topic of interest for researchers, political agents, health professionals and inspection agents. These substances are designed to mimic the pharmacological effects of common illicit drugs. A major obstacle in the discovery of psychopharmacological agents is the difficulty in predicting how candidate drugs might alter behavior. Animal experiments are standard practice for hypothesis testing in preclinical research. Zebrafish (Danio rerio) has emerged as a species of choice in experimental studies in pharmacology, where it is used in high-throughput drug screening of various psychoactive compounds. Therefore, the usefulness of zebrafish in neuroscience research is growing rapidly due to its high physiological and genetic homology with humans, ease of genetic manipulation, robust behaviors and cost-effectiveness. Therefore, based on these assumptions, the objective of this study is to verify in the scientific literature the results of using Zebrafish as an experimental model in the study of psychoactive substances. This was a literature review study. Through the present study, it was possible to realize that Zebrafish can be used to assess the toxicity of drug candidates in initial screening trials, sometimes in a high-throughput way. Thus, it is seen that complementing rodents, Zebrafish is an important organism for the study of mechanisms of normal and pathological behavior, as well as for central nervous system disease modeling, drug development and high-throughput drug screening, such as psychoactive drugs.
The emergence of New Psychoactive Substances has become a topic of interest for researchers, political agents, health professionals and inspection agents. These substances are designed to mimic the pharmacological effects of common illicit drugs. A major obstacle in the discovery of psychopharmacological agents is the difficulty in predicting how candidate drugs might alter behavior. Animal experiments are standard practice for hypothesis testing in preclinical research. Zebrafish (Danio rerio) has emerged as a species of choice in experimental studies in pharmacology, where it is used in high-throughput drug screening of various psychoactive compounds. Therefore, the usefulness of zebrafish in neuroscience research is growing rapidly due to its high physiological and genetic homology with humans, ease of genetic manipulation, robust behaviors and cost-effectiveness. Therefore, based on these assumptions, the objective of this study is to verify in the scientific literature the results of using Zebrafish as an experimental model in the study of psychoactive substances. This was a literature review study. Through the present study, it was possible to realize that Zebrafish can be used to assess the toxicity of drug candidates in initial screening trials, sometimes in a high-throughput way. Thus, it is seen that complementing rodents, Zebrafish is an important organism for the study of mechanisms of normal and pathological behavior, as well as for central nervous system disease modeling, drug development and high-throughput drug screening, such as psychoactive drugs.
Palavras-chave
Efeitos farmacológicos., Substâncias Psicoativas., Zebrafish.