Efeitos farmacológicos dos ácidos ursólico e oleanólico presentes na Ixora coccinea Linn
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Data
2022-12-14
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso fechado
Editora
Autores
Silva, Ideane Claudia da
Costa, Williane Stephanie Sales
Orientador
Ferreira, Caio Fernando Martins
Coorientador
Resumo
No Brasil, é bastante comum o uso de plantas para uso recreativo, medicinal e artigos ambientais para fins decorativos. A Ixora coccínea, também conhecida popularmente como flor de coral, é utilizada na medicina tradicional indiana, além de utilizar os frutos da planta como fonte de alimento, outras partes da planta são usadas para tratar doenças, como: hipertensão, leucorreia, hemoptise, alterações menstruais, dentre outras. Além do mais, foi comprovada a ação antioxidante e antimicrobiana do extrato etanólico das flores e folhas da Ixora. As atividades farmacológicas do ácido ursólico e oleanólico foram extensivamente estudadas nos últimos anos e vários relatórios revelaram que os ácidos possuem atividades biológicas, que incluem anti-inflamatório, antioxidante e anticâncer. O objetivo deste trabalho, é proporcionar maiores esclarecimentos acerca de suas propriedades fitoquímicas da Ixora coccinea, dissertando sobre seus possíveis usos farmacológicos e, consequentemente, investigar informações sobre seus desempenhos terapêuticos. Trata-se de uma revisão de literatura, utilizando as bases de dados como: Scientific Eletronic Library Online (SciELO), Science Direct, Pubmed e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) nos períodos de 2012 a 2022, além de pesquisa de patentes através das plataformas Patentscope, Espacenet e INPI - Intituto Nacional da Propriedade Intelectual. Diante de uma série de estudos com a erva medicinal Ixora coccinea, houve uma comprovação das atividades farmacológicas de ações terapêuticas. Isto mostra que a Ixora coccinea juntamente com os seus óleos ursólico e oleanólico em sua composição, é bastante importante para a ciência. Por esse motivo, é de suma importância que se estude sobre as plantas medicinais e seus potenciais terapêuticos, nelas ainda contém substâncias desconhecidas e pouco retratadas na literatura, portanto pode-se desvendar curas para determinadas patologias.
In Brazil, it is quite common to use plants for recreational, medicinal and environmental purposes for decorative purposes. Ixora coccinea, also popularly known as coral flower, is used in traditional Indian medicine, in addition to using the fruits of the plant as a food source, other parts of the plant are used to treat diseases such as: hypertension, leukorrhea, hemoptysis, alterations menstruation, among others. Furthermore, the antioxidant and antimicrobial action of the ethanolic extract of Ixora flowers and leaves has been proven. The pharmacological activities of ursolic and oleanolic acid have been extensively studied in recent years and several reports have revealed that the acids possess biological activities, which include anti-inflammatory, antioxidant and anti-cancer activities. The objective of this work is to provide further clarification about the phytochemical properties of Ixora coccinea, discussing its possible pharmacological uses and, consequently, investigating information about its therapeutic performance. This is a literature review, using databases such as: Scientific Electronic Library Online (SciELO), Science Direct, Pubmed and Latin American and Caribbean Literature in Health Sciences (LILACS) from 2012 to 2022, in addition to patent research through the Patentscope, Espacenet and INPI - National Institute of Intellectual Property platforms. In the face of a series of studies with the medicinal herb Ixora coccinea, there was a confirmation of the pharmacological activities of therapeutic actions. This shows that Ixora coccinea together with its ursolic and oleanolic oils in its composition, is quite important for science. For this reason, it is of paramount importance to study medicinal plants and their therapeutic potential, they still contain unknown substances and little portrayed in the literature, so cures for certain pathologies can be discovered.
In Brazil, it is quite common to use plants for recreational, medicinal and environmental purposes for decorative purposes. Ixora coccinea, also popularly known as coral flower, is used in traditional Indian medicine, in addition to using the fruits of the plant as a food source, other parts of the plant are used to treat diseases such as: hypertension, leukorrhea, hemoptysis, alterations menstruation, among others. Furthermore, the antioxidant and antimicrobial action of the ethanolic extract of Ixora flowers and leaves has been proven. The pharmacological activities of ursolic and oleanolic acid have been extensively studied in recent years and several reports have revealed that the acids possess biological activities, which include anti-inflammatory, antioxidant and anti-cancer activities. The objective of this work is to provide further clarification about the phytochemical properties of Ixora coccinea, discussing its possible pharmacological uses and, consequently, investigating information about its therapeutic performance. This is a literature review, using databases such as: Scientific Electronic Library Online (SciELO), Science Direct, Pubmed and Latin American and Caribbean Literature in Health Sciences (LILACS) from 2012 to 2022, in addition to patent research through the Patentscope, Espacenet and INPI - National Institute of Intellectual Property platforms. In the face of a series of studies with the medicinal herb Ixora coccinea, there was a confirmation of the pharmacological activities of therapeutic actions. This shows that Ixora coccinea together with its ursolic and oleanolic oils in its composition, is quite important for science. For this reason, it is of paramount importance to study medicinal plants and their therapeutic potential, they still contain unknown substances and little portrayed in the literature, so cures for certain pathologies can be discovered.
Palavras-chave
Ixora coccinea, Ixora, Ácido ursólico, Ácido oleanólico, Plantas medicinais