Characteristics Associated to Lipodystrophy Syndrome among HIVInfected Patients Naive and on Antiretroviral Treatment

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dc.contributor.authorAlencastro, Paulo Ricardo
dc.contributor.authorWolff, Fernando Hertz
dc.contributor.authorSchuelter-Trevisol, Fabiana
dc.contributor.authorIkeda, Maria Letícia
dc.contributor.authorBrandão, Ajácio Bandeira de Mello
dc.contributor.authorBarcellos, Nêmora T.
dc.contributor.authorFuchs, Sandra Costa
dc.coverage.spatialCalifórniapt_BR
dc.date.accessioned2017-09-12T19:57:09Z
dc.date.accessioned2020-11-26T17:41:32Z
dc.date.available2017-09-12T19:57:09Z
dc.date.available2020-11-26T17:41:32Z
dc.date.issued2012
dc.description.abstractAbstract Background: HIV-associated lipodystrophy involves changes in complex metabolic networks that are associated with increased cardiovascular risk. It has been associated with the use of combined antiretroviral treatment (cART), particularly Protease Inhibitors (PI) and thymidine analogs. This study aims to evaluate characteristics and use of ART associated with lipodystrophy, lipohypertrophy, and lipoatrophy among HIV-infected patients. Methods: A cross-sectional study was conducted in HIV-infected patients of both genders, aged 18 years or older, who sought care at an HIV/AIDS referral service for diagnostic confirmation or treatment between June 2006 and December 2008. Results: 1240 out of 1295 patients with HIV infection were included. Among patients on cART, women had a higher risk of lipohypertrophy than men, as well as a time since diagnosis of HIV greater than 6 years (versus <3 years). For lipoatrophy, age, education, lifestyle, and body mass index were associated with increased risk. Metabolic parameters were higher among patients on ART; and cART and PI use were independently associated with lipohypertrophy, lipoatrophy and lipodystrophy. The use of PI can be regarded as responsible for 13% of the association of ART and lipodystrophy, and of 11.5% for the thymidine analogs use, independent of gender, skin color, smoking, CD4, and BMI. Conclusions: Risk factors for lipodystrophy, lipoatrophy and lipohypertrophy are marked among ART users, but also among ART naïve patients.pt_BR
dc.format.extent1-9pt_BR
dc.identifier.issn2155-6113pt_BR
dc.identifier.urihttp://dx.doi.org/10.4172/2155-6113.1000182pt_BR
dc.identifier.urihttps://repositorio.animaeducacao.com.br/handle/ANIMA/2677
dc.language.isoen_USpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectHIVpt_BR
dc.subjectLipodystrophypt_BR
dc.subjectLipohypertrophypt_BR
dc.subjectLipoatrophypt_BR
dc.subjectRisk factorspt_BR
dc.subjectHAARTpt_BR
dc.subjectDyslipidemiapt_BR
dc.titleCharacteristics Associated to Lipodystrophy Syndrome among HIVInfected Patients Naive and on Antiretroviral Treatmentpt_BR
dc.typeArtigo de Periodicopt_BR
local.affiliation.iesUnisul
local.author.cursoProdução Científicapt_BR
local.author.unidadeÂnimapt_BR
local.rights.policyAcesso abertopt_BR
local.subject.areaCiências da Saúdept_BR
local.subject.areaanimaCiências Humanaspt_BR

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