Efeitos terapêuticos da Cúrcuma longa l. no tratamento da aterosclerose: uma revisão narrativa.
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
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Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
BRITO, Jônatas Miquéias Fernandes
CAVALCANTE, Marcos Antonio Maia
Orientador
MENDONÇA, Cândida Maria Soares de
Coorientador
Resumo
A revisão bibliográfica e narrativa constituiu-se de uma análise sobre os efeitos fitoterápicos dos princípios ativos fitoterápicos da Cúrcuma longa L. na fisiopatologia aterosclerótica. A aterosclerose é uma doença proveniente da formação de placas de ateroma no tecido endotelial das artérias de grande e médio calibre, levando o corpo à uma resposta inflamatória que pode gerar a obstrução dos vasos e consequências complexas à saúde do organismo. O objetivo deste estudo é realizar uma revisão literária e narrativa para analisar as propriedades fitoquímicas da Cúrcuma longa L. e seus efeitos fitoterápicos na aterosclerose. Esta é uma revisão de literatura realizada pelas bases de dados ScienceDirect, PubMed, SciELO e LILACS, buscado pelas terminologias: “Curcumin” “Plant Extracts”, “Atherosclerosis”, “Experimental Animal Models” e “Pathology” tendo como estratégia de busca os operadores booleanos “and” ou “or” entre elas para filtragem dos estudos. Foram selecionados 5 estudos elegíveis para elaboração dos resultados. Foram observados resultados significativos na supressão da proliferação celular, diminuição de citocinas pró-inflamatórias, na redução das concentrações de colesterol-LDL plasmático e aumento das concentrações de colesterol-HDL plasmático, auxiliando também na inibição da oxidação das moléculas de LDL, influenciando ainda, no aumento das atividades de enzimas antioxidantes. Sendo assim, os efeitos dos princípios ativos da Cúrcuma longa L. mostraram resultados promissores para a melhoria de sinais e sintomas clínicos em modelos da fisiopatologia aterosclerótica, porém os estudos ainda são preliminares, pois se limitam a experimentos de modelos em animais. Portanto, ensaios clínicos são necessários para extrapolar os resultados de estudos experimentais para humanos.
The bibliographical and narrative review consisted of an analysis of the phytotherapeutic effects of the active principles of Turmeric (Cúrcuma longa L.) on atherosclerotic pathophysiology. Atherosclerosis is a disease caused by the formation of atheromatous plaques in the endothelial tissue of large and medium sized arteries, leading the body to an inflammatory response that can lead to vessel obstruction and complex consequences for the body's health. The aim of this study is to carry out a literature and narrative review to analyze the phytochemical properties of Turmeric (Cúrcuma longa L.) and its phytotherapeutic effects on atherosclerosis. This is a literature review carried out using the ScienceDirect, PubMed, SciELO and LILACS databases, searching for the following terminologies: "Curcumin", "Plant Extracts", "Atherosclerosis", "Experimental Animal Models" and "Pathology", using the Boolean operators "and" or "or" to filter the studies. Five eligible studies were selected for analysis of the results. Significant results were observed in suppressing cell proliferation, decreasing pro-inflammatory cytokines, reducing plasma LDL-cholesterol concentrations and increasing plasma HDL cholesterol concentrations, as well as helping to inhibit the oxidation of LDL molecules and increasing the activity of antioxidant enzymes. Thus, the effects of the active principles of Turmeric (Cúrcuma longa L.) have shown promising results for improving clinical signs and symptoms in models of atherosclerotic pathophysiology, but the studies are still preliminary, as they are limited to animal model experiments. Clinical trials are therefore needed to extrapolate the results of experimental studies to humans.
The bibliographical and narrative review consisted of an analysis of the phytotherapeutic effects of the active principles of Turmeric (Cúrcuma longa L.) on atherosclerotic pathophysiology. Atherosclerosis is a disease caused by the formation of atheromatous plaques in the endothelial tissue of large and medium sized arteries, leading the body to an inflammatory response that can lead to vessel obstruction and complex consequences for the body's health. The aim of this study is to carry out a literature and narrative review to analyze the phytochemical properties of Turmeric (Cúrcuma longa L.) and its phytotherapeutic effects on atherosclerosis. This is a literature review carried out using the ScienceDirect, PubMed, SciELO and LILACS databases, searching for the following terminologies: "Curcumin", "Plant Extracts", "Atherosclerosis", "Experimental Animal Models" and "Pathology", using the Boolean operators "and" or "or" to filter the studies. Five eligible studies were selected for analysis of the results. Significant results were observed in suppressing cell proliferation, decreasing pro-inflammatory cytokines, reducing plasma LDL-cholesterol concentrations and increasing plasma HDL cholesterol concentrations, as well as helping to inhibit the oxidation of LDL molecules and increasing the activity of antioxidant enzymes. Thus, the effects of the active principles of Turmeric (Cúrcuma longa L.) have shown promising results for improving clinical signs and symptoms in models of atherosclerotic pathophysiology, but the studies are still preliminary, as they are limited to animal model experiments. Clinical trials are therefore needed to extrapolate the results of experimental studies to humans.
Palavras-chave
curcumina, terapia, fitoquímicos