A interferência dos anti-hipertensivos em exames de bioquímica: uma revisão de literatura
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Data
2023-12
Tipo de documento
Artigo Científico
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Área do conhecimento
Modalidade de acesso
Acesso aberto
Editora
Autores
GOMES, Alana Battistello
Lisiane
Orientador
VAZ, Lisiane
Coorientador
Resumo
Objetivo: Identificar quais os principais fármacos anti-hipertensivos que podem modular o exame laboratorial; Identificar quais os principais exames bioquímicos propensos a sofrerem alterações em decorrência dos medicamentos; demonstrar, dentre os medicamentos anti-hipertensivos, como os fármacos podem modular os resultados de exames bioquímicos. Metodologia: Estudo de revisão narrativa da literatura com busca nas bases de dados PUBMED, Google Acadêmico e SCIELO nos idiomas português, espanhol e inglês, abrangendo artigos publicados entre os anos de 2013 e 2023. Foram utilizados os descritores “hipertensão arterial (arterial hypertension), anti-hipertensivos (anti hypertensive), exames de bioquímica (biochemistry exams), interferentes medicamentosos (drug interferences), exame médico (medical examination), exames bioquímicos clínicos (clinical chemistry tests), utilizando-se os critérios de arranjo e combinação AND e OR. Resultados: os fármacos mais citados por apresentarem alterações em exames de bioquímica foram os anti-hipertensivos captopril, enalapril, atenolol, propranolol e losartana potássica e o diurético hidroclorotiazida que causam aumentos e/ou diminuições em análises de dosagens quantitativas e falso-positivo/negativo em dosagens qualitativas nos exames de creatinina, ureia, sódio, potássio, ácido úrico, fosfatase alcalina, FAN, AST, ALT, triglicerídeos, colesterol total, HDL e LDL, cálcio, bilirrubinas, corpos cetônicos, glicose, cloro, magnésio e amilase. Conclusão: A revisão de literatura pôde apontar as medicações anti-hipertensivas que causam interferências nos exames bioquímicos, assim como, identificou os principais exames que sofrem alterações, no entanto, não foi possível indicar o mecanismo de ação envolvido e o intervalo necessário entre o uso da medicação e a coleta de exame. Dessa forma, sugere-se a necessidade de estudos sobre essa temática.
Objective: Identify which are the main antihypertensive drugs that can modulate the laboratory test; Identify which main biochemical tests are likely to change as a result of medications; demonstrate, among antihypertensive medications, how drugs can modulate the results of biochemical tests. Methodology: Narrative literature review study with search in the PUBMED, Google Scholar and SCIELO databases in Portuguese, Spanish and English, covering articles published between 2013 and 2023. The descriptors were used “arterial hypertension, anti hypertensive, biochemistry exams, drug interferences, medical examination, clinical chemistry tests using the arrangement and combination criteria AND and OR. Results: the drugs most cited for presenting changes in biochemistry tests were the antihypertensives captopril, enalapril, atenolol, propranolol and losartan potassium and the diuretic hydrochlorothiazide, which cause increases and/or decreases in quantitative dosage analyzes and false-positive/negative dosages qualitative tests for creatinine, urea, sodium, potassium, uric acid, alkaline phosphatase, ANA, AST, ALT, triglycerides, total cholesterol, HDL and LDL, calcium, bilirubin, ketone bodies, glucose, chlorine, magnesium and amylase. Conclusion: The literature review can point out antihypertensive medications that cause interference in biochemical tests, as well as identifying the main tests that undergo changes, however, it was not possible to indicate the mechanism of action involved and the necessary interval between use medication and test collection. Therefore, the need for studies on this topic is suggested.
Objective: Identify which are the main antihypertensive drugs that can modulate the laboratory test; Identify which main biochemical tests are likely to change as a result of medications; demonstrate, among antihypertensive medications, how drugs can modulate the results of biochemical tests. Methodology: Narrative literature review study with search in the PUBMED, Google Scholar and SCIELO databases in Portuguese, Spanish and English, covering articles published between 2013 and 2023. The descriptors were used “arterial hypertension, anti hypertensive, biochemistry exams, drug interferences, medical examination, clinical chemistry tests using the arrangement and combination criteria AND and OR. Results: the drugs most cited for presenting changes in biochemistry tests were the antihypertensives captopril, enalapril, atenolol, propranolol and losartan potassium and the diuretic hydrochlorothiazide, which cause increases and/or decreases in quantitative dosage analyzes and false-positive/negative dosages qualitative tests for creatinine, urea, sodium, potassium, uric acid, alkaline phosphatase, ANA, AST, ALT, triglycerides, total cholesterol, HDL and LDL, calcium, bilirubin, ketone bodies, glucose, chlorine, magnesium and amylase. Conclusion: The literature review can point out antihypertensive medications that cause interference in biochemical tests, as well as identifying the main tests that undergo changes, however, it was not possible to indicate the mechanism of action involved and the necessary interval between use medication and test collection. Therefore, the need for studies on this topic is suggested.
Palavras-chave
anti-hipertensivos, exames de bioquímica, interferências nos exames.