A utilização sistemas de liberação de fármacos aplicados a anti-inflamatórios: revisão sistemática
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Data
2021-12-04
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso fechado
Editora
Autores
Silva, Emerson Rodrigues
Oliveira, Lindonara Pereira de
Orientador
Castro, Diana Rodrigues
Coorientador
Resumo
Este artigo apresenta como objetivo uma revisão de literatura reunindo novos estudos de aplicação de sistemas de liberação de fármacos a anti-inflamatórios. A busca pelas publicações ocorreu nas bases de dados SciELO (Cientificar Eletronic Library online), BVS (Biblioteca virtual em saúde), Google acadêmico (Google Scholar), MEDLINE (Medical Literature Analysis and Retrieval System Online) e PUBMED (National Library of Medicine). Muitos estudos associam o uso de anti-inflamatórios a efeitos adversos incômodos, tais como as lesões gastrointestinais, se tratando de fármacos eficazes no manejo do combate a processos inflamatórios e por seu uso ter crescido ao longo dos anos, aperfeiçoar o modo como esses medicamentos agem no organismo é de grande importância. Quando comparados aos métodos convencionais os sistemas de liberação controlada possibilita que o perfil de concentração do fármaco se mantenha constante dentro da faixa terapêutica promovendo dessa forma, aumento do índice terapêutico e provendo uma melhor adesão ao paciente. Sendo esses sistemas com os mais variados mecanismos de entrega, que vai desde nanomateriais que simplifica a administração ou um dos mais usados atualmente os lipossomas, onde se pode encapsular fármacos hidrofóbicos e hidrofílicos, assim ter resultados como a melhora da biodisponibilidade desses medicamentos. Levando esses fatores em consideração é possível estudar a aplicação de novos sistemas de liberação de fármacos a anti-inflamatórios, o que possibilitaria tanto no ajuste de dose terapêutica, quanto na forma de entrega desse fármaco no organismo e deduzindo, por tanto a redução dos efeitos indesejáveis.
This article presents as its objective a literature review bringing together new studies on the application of drug delivery systems to anti-inflammatory drugs. The search for publications took place in the SciELO (Scientify Electronic Library online), BVS (Virtual Health Library), Academic Google (Google Scholar), MEDLINE (Medical Literature Analysis and Retrieval System Online) and PUBMED (National Library of Medicine) databases. Many studies associate the use of anti-inflammatory drugs with uncomfortable adverse effects, such as gastrointestinal injuries, as they are effective drugs in the management of combating inflammatory processes and because their use has grown over the years, improve the way these drugs act in the body is of great importance. When compared to conventional methods, controlled release systems allow the drug concentration profile to remain constant within the therapeutic range, thus promoting an increase in the therapeutic index and providing better patient compliance. These systems have the most varied delivery mechanisms, ranging from nanomaterials that simplify administration or one of the most currently used liposomes, where hydrophobic and hydrophilic drugs can be encapsulated, thus having results such as improving the bioavailability of these drugs. Taking these factors into account, it is possible to study the application of new drug delivery systems to anti-inflammatory drugs, which would enable both the adjustment of the therapeutic dose and the way in which this drug is delivered to the body, thus deducing the reduction of effects undesirable.
This article presents as its objective a literature review bringing together new studies on the application of drug delivery systems to anti-inflammatory drugs. The search for publications took place in the SciELO (Scientify Electronic Library online), BVS (Virtual Health Library), Academic Google (Google Scholar), MEDLINE (Medical Literature Analysis and Retrieval System Online) and PUBMED (National Library of Medicine) databases. Many studies associate the use of anti-inflammatory drugs with uncomfortable adverse effects, such as gastrointestinal injuries, as they are effective drugs in the management of combating inflammatory processes and because their use has grown over the years, improve the way these drugs act in the body is of great importance. When compared to conventional methods, controlled release systems allow the drug concentration profile to remain constant within the therapeutic range, thus promoting an increase in the therapeutic index and providing better patient compliance. These systems have the most varied delivery mechanisms, ranging from nanomaterials that simplify administration or one of the most currently used liposomes, where hydrophobic and hydrophilic drugs can be encapsulated, thus having results such as improving the bioavailability of these drugs. Taking these factors into account, it is possible to study the application of new drug delivery systems to anti-inflammatory drugs, which would enable both the adjustment of the therapeutic dose and the way in which this drug is delivered to the body, thus deducing the reduction of effects undesirable.
Palavras-chave
anti-inflamatórios; sistemas de liberação de fármacos; estudos recentes; drug delivery; AINES.