Medicina Veterinária
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Navegando Medicina Veterinária por Autor "Adam, Alexandra"
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Monografia Acesso embargado Efeito da curcumina sobre os marcadores de estresse oxidativo em cães com osteoartrite(2017) Adam, AlexandraOsteoarthritis is a chronic, progressive and degenerative disease, driven by inflammation, that commonly affects dogs. There is no cure, largely due to the fact that, at present, there are not any effective therapeutic agents for repairing joint integrity. It is clinically characterized by lameness, functional disabilities, crepitus, joint stiffness, muscle atrophy and pain. Nonetheless, early findings suggest that curcumin has anti-inflammatory and antioxidant properties, among many others, making it a promising agent for osteoarthritis treatment therapy, thereby reducing the inflammation and suppressing the level of reactive oxygen species - which, at elevated rates, can mediate and produce harmful effects on cells, causing damage to membranes, cytoplasm and, further, to the deoxyribonucleic acid. The purpose of the research was to evaluate the curcumin’s effect on markers of lipid oxidative damage. This study was performed at the Unisul Veterinary Hospital, involving 4 large dogs (three females and one male, all older than 9 years), diagnosed with osteoarthritis secondary to hip dysplasia, which were treated for ten days after inclusion. The experiment conduction was uniform, and the treatment consisted of ten consecutive once-daily oral combined administration of chondroprotectives agents (chondroitin sulfate and glucosamine) and curcumin as adjuvant. Blood was collected before and after the treatment, in order to perform the analysis of the oxidative damage to lipids, and determine hematological parameters, with liver and renal function profiles. The adopted measure of evidence (p-value) was greater than the significance level defined for this study (α = 0.05), although there was a reduction in the oxidative damage in 75% of sample members, which can be attributed to the curcumin’s antioxidant effect on chondrocytes and cytokines. Due to the limitations of this study, especially those related to the constrained time to complete the research, no greater reduction of lipid damage could be observed. Nevertheless, the findings of this study revealed a positive effect of curcumin on markers of oxidative stress, as well as an improvement of hematological (mainly leukocyte-related) parameters.