Associação da Glicemia de Admissão e a Função Ventricular pós Infarto Agudo do Miocárdio
Carregando...
Arquivos
Data
2024-06
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Modalidade de acesso
Acesso fechado
Editora
Autores
BATTISTI, Gabriel Augusto Mattei
CAMINHA, Manoela Heineck
MOREIRA, Daniel Medeiros
Orientador
MOREIRA, Daniel Medeiros
Coorientador
Resumo
INTRODUÇÃO: A relação entre a glicemia e o aumento do risco cardiovascular bem
como a Fração de Ejeção do Ventrículo Esquerdo (FEVE) como indicação de função
cardíaca já são de amplo conhecimento pela comunidade médica, mas novos
trabalhos correlacionando a glicemia e a FEVE pós infarto são necessários.
OBJETIVO: Avaliar se existe associação entre a glicemia de admissão e a FEVE pós
infarto. METODOLOGIA: Estudo de Coorte aninhado ao Catarina Heart Study. Foram
avaliados 1404 pacientes admitidos em emergência cardiológica com o diagnóstico
de primeiro IAM entre Julho de 2016 e Maio de 2024. Os desfechos avaliados foram
a associação do nível glicêmico de admissão com a FEVE pós-IAM, associação de
MACE em 1 ano com níveis glicêmicos de admissão e descrever as características
sociodemográficas e clínicas da população em estudo. RESULTADOS: Entre 2016-
2024 foram analisados 1404 pacientes. Quando avaliada a associação entre a
glicemia e FEVE existe uma correlação fraca e negativa (r=-0,211, p<0,001). Além
disso, quartis de glicemia mais altos estão associados com mediana mais baixa de
FEVE (>Percentil 75=49,00 (42,00-58,00); >Percentil 50 ≤Percentil 75=50,50 (44,00-
60,75); >Percentil 25 ≤Percentil 50=51,00 (40,75-59,25); ≤Percentil 25=57,00 (45,00-
63,00); p=0,018). Há uma associação entre o maior quartil de glicemia com aumento
de incidência de MACE em 1 ano (HR 7,17 (IC 1,60-32,40), p=0,010). CONCLUSÃO:
Foi evidenciada uma correlação negativa entre a glicemia de chegada e a FEVE em
pacientes pós-IAM. Houve associação entre o mais alto quartil de glicemia e aumento
de MACE em 1 ano.
INTRODUCTION: The association between blood glucose levels and increased cardiovascular risk, as well as the Left Ventricular Ejection Fraction (LVEF) as an indication of cardiac function, is already widely known by the medical community. However, new studies correlating blood glucose levels and LVEF post-myocardial infarction are necessary. OBJECTIVE: To assess whether there is an association between admission blood glucose levels and LVEF post-myocardial infarction. METHODOLOGY: A cohort study nested within the Catarina Heart Study. A total of 1404 patients admitted to the cardiac emergency department with a diagnosis of first myocardial infarction between July 2016 and May 2024 were evaluated. The outcomes assessed were the association of admission blood glucose level with LVEF postmyocardial infarction, the association of MACE within one year with admission blood glucose levels, and the description of the sociodemographic and clinical characteristics of the study population. RESULTS: Between 2016 and 2024, 1404 patients were analyzed. When evaluating the association between blood glucose levels and LVEF, there is a weak and negative correlation (r=-0.211, p<0.001). Additionally, higher quartiles of blood glucose are associated with a lower median LVEF (>75th percentile=49.00 (42.00-58.00); >50th percentile ≤75th percentile=50.50 (44.00-60.75); >25th percentile ≤50th percentile=51.00 (40.75-59.25); ≤25th percentile=57.00 (45.00-63.00); p=0.018). There is an association between the highest quartile of blood glucose and an increased incidence of MACE within one year (HR 3.03 (CI 1.07-8.59), p=0.037). CONCLUSION: A negative correlation between admission blood glucose levels and LVEF in post-myocardial infarction patients was evidenced. There was an association between the highest quartile of blood glucose and an increase in MACE within one year.
INTRODUCTION: The association between blood glucose levels and increased cardiovascular risk, as well as the Left Ventricular Ejection Fraction (LVEF) as an indication of cardiac function, is already widely known by the medical community. However, new studies correlating blood glucose levels and LVEF post-myocardial infarction are necessary. OBJECTIVE: To assess whether there is an association between admission blood glucose levels and LVEF post-myocardial infarction. METHODOLOGY: A cohort study nested within the Catarina Heart Study. A total of 1404 patients admitted to the cardiac emergency department with a diagnosis of first myocardial infarction between July 2016 and May 2024 were evaluated. The outcomes assessed were the association of admission blood glucose level with LVEF postmyocardial infarction, the association of MACE within one year with admission blood glucose levels, and the description of the sociodemographic and clinical characteristics of the study population. RESULTS: Between 2016 and 2024, 1404 patients were analyzed. When evaluating the association between blood glucose levels and LVEF, there is a weak and negative correlation (r=-0.211, p<0.001). Additionally, higher quartiles of blood glucose are associated with a lower median LVEF (>75th percentile=49.00 (42.00-58.00); >50th percentile ≤75th percentile=50.50 (44.00-60.75); >25th percentile ≤50th percentile=51.00 (40.75-59.25); ≤25th percentile=57.00 (45.00-63.00); p=0.018). There is an association between the highest quartile of blood glucose and an increased incidence of MACE within one year (HR 3.03 (CI 1.07-8.59), p=0.037). CONCLUSION: A negative correlation between admission blood glucose levels and LVEF in post-myocardial infarction patients was evidenced. There was an association between the highest quartile of blood glucose and an increase in MACE within one year.
Palavras-chave
Glicemia. Fração de ejeção. Infarto agudo do miocárdio. Diabetes Mellitus