Eixo intestino-cérebro: correlação da microbiota intestinal com o transtorno de depressão maior.
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Data
2023-12
Tipo de documento
Artigo Científico
Título da Revista
ISSN da Revista
Título de Volume
Área do conhecimento
Ciências da Saúde
Modalidade de acesso
Acesso aberto
Editora
Autores
BECMAN, Carolina Silveira
NASCIMENTO, Mariana Andrade do
RIVAS, Mariana Ramos Bueno
Orientador
OLIVEIRA, Omara Machado Araujo de
Coorientador
Resumo
A função cerebral é influenciada pelo equilíbrio da microbiota intestinal, o qual pode impactar no desenvolvimento de transtornos neuropsiquiátricos, como o transtorno da depressão maior (TDM). Nesse sentido, a presente revisão objetiva aprofundar a relação entre a microbiota e a depressão, de modo a concluir se o controle da disbiose intestinal por meio de tratamentos nutricionais e suplementação de psicobióticos interfere nos sintomas dessa patologia. Para tais fins, examina-se a fisiologia do eixo intestino-cérebro, discutindo as evidências científicas que sugerem uma ligação entre a saúde gastrointestinal e a depressão, considerando o potencial de intervenções dietéticas e de suplementações psicobióticas no tratamento do TDM. Trata-se de revisão narrativa que apresenta análise geral sobre o tema em referência, por meio do estudo de bibliografias científicas. Foram considerados artigos contendo estudos clínicos e pré-clínicos, revisões e meta-análise, além de pesquisas originais. Conclui-se que há dados suficientes para viabilizar o uso de psicobióticos como terapia coadjuvante ao tratamento com fármacos ao TDM. Por meio da modulação intestinal, há maior estímulo para a síntese e metabolismo de substâncias neuroprotetoras, resultando na melhora de sintomas psicológicos. A estratégia dietoterápica que apresenta melhores resultados é voltada para uma alimentação anti-inflamatória alinhada à suplementação de probióticos de multiespécies em grandes dosagens e em curto período, demonstra-se que a nutrição tem papel essencial para promover saúde e equilíbrio ao organismo por contribuir para a prevenção de transtornos psiquiátricos, mas também outras patologias distintas.
Brain function is influenced by the balance of the intestinal microbiota, which can impact the development of neuropsychiatric disorders, such as major depression disorder (MDD). This review delves into the relationship between microbiota and depression, to conclude whether the control of intestinal dysbiosis through nutritional treatments and psychobiotic supplementation interferes with the symptoms of this pathology. To these ends, the physiology of the gut-brain axis is examined, discussing the scientific evidence that suggests a link between gastrointestinal health and depression, considering the potential of dietary interventions and psychobiotic supplements in the treatment of MDD. This is a narrative review that presents a general analysis of the topic in question, through the study of scientific bibliographies. Articles that contained clinical and pre-clinical studies, reviews, and meta-analyses, as well as original research were considered. In conclusion, sufficient data were found to enable the use of psychobiotics as an adjunctive therapy to medication treatment for MDD. Through intestinal modulation, there is greater stimulation for the 2 synthesis and metabolism of neuroprotective substances, resulting in an improvement in psychological symptoms. The nutrition therapy strategy that presents the best results is focused on a controlled anti-inflammatory diet and the supplementation of probiotics from multiple species in large doses and in a short period of time, demonstrating that nutrition plays an essential role in promoting health and balance in the body by contributing to the prevention of psychiatric disorders, but also other distinct pathologies.
Brain function is influenced by the balance of the intestinal microbiota, which can impact the development of neuropsychiatric disorders, such as major depression disorder (MDD). This review delves into the relationship between microbiota and depression, to conclude whether the control of intestinal dysbiosis through nutritional treatments and psychobiotic supplementation interferes with the symptoms of this pathology. To these ends, the physiology of the gut-brain axis is examined, discussing the scientific evidence that suggests a link between gastrointestinal health and depression, considering the potential of dietary interventions and psychobiotic supplements in the treatment of MDD. This is a narrative review that presents a general analysis of the topic in question, through the study of scientific bibliographies. Articles that contained clinical and pre-clinical studies, reviews, and meta-analyses, as well as original research were considered. In conclusion, sufficient data were found to enable the use of psychobiotics as an adjunctive therapy to medication treatment for MDD. Through intestinal modulation, there is greater stimulation for the 2 synthesis and metabolism of neuroprotective substances, resulting in an improvement in psychological symptoms. The nutrition therapy strategy that presents the best results is focused on a controlled anti-inflammatory diet and the supplementation of probiotics from multiple species in large doses and in a short period of time, demonstrating that nutrition plays an essential role in promoting health and balance in the body by contributing to the prevention of psychiatric disorders, but also other distinct pathologies.
Palavras-chave
Eixo intestino-cérebro, Microbiota intestinal, Disbiose, Depressão, Distúrbios psiquiátricos